Noncovalent PEGylation of l-Asparaginase Using PEGylated Polyelectrolyte
نویسندگان
چکیده
منابع مشابه
A PEGylation technology of L-asparaginase with monomethoxy polyethylene glycol-propionaldehyde.
Polyethylene glycol (PEG) conjugation technology has been successfully applied to improve the performance of protein drugs. In this study, L-asparaginase was N-terminal site-specifically modified by alkylating PEG with monomethoxy polyethylene glycol-propionaldehyde (mPEG-ALD20000). The optimum reaction parameters were determined as pH 5.0, a molar ratio of mPEG-ALD2000 to L-asparaginase of 10:...
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ژورنال
عنوان ژورنال: Journal of Pharmaceutical Sciences
سال: 2015
ISSN: 0022-3549
DOI: 10.1002/jps.24217